Figure 2.

Platelet function alterations over time following TBI, dependent on prehospital cyclooxygenase (COX) inhibitor treatment. Patients with COX inhibitor treatment before hospital admission demonstrated a consistently lower arachidonic acid receptor (ASPI) value compared with those without COX inhibitor treatment (A), as showed by the two LOWESS curves. The black dashed line denotes the ASPI reference interval (71–115 AU). At one time point, however, there was a partial overlap, which, as shown in panel (B), might be explained by an increase in platelet transfusions at the time point preceding the overlapping LOWESS curves in panel (A). Abbreviations: AU, area under the curve; LOWESS, locally weighted scatterplot smoother; TBI, traumatic brain injury.