Table 4.
Univariate analysis of variables and correlations to final GOS.
| Independent variable | pValue | Pseudo-R2 |
|---|---|---|
| Base model | ||
| Age | 0.0008 | 0.067 |
| GCS at admission | <0.0001 | 0.167 |
| Pupil responsiveness | 0.0070, <0.0001 | 0.130 |
| Stockholm CT score | <0.0001 | 0.208 |
| Oxygen saturation at SoA | 0.0282 | 0.044 |
| Blood pressure at SoA | 0.1401 | NS |
| Additional variables assessed | ||
| Injury Severity Score | 0.4317 | NS |
| ASPI, 1st value | 0.0389 | 0.026 |
| ADP, 1st value | 0.2874 | NS |
| TRAP, 1st value | 0.0086 | 0.042 |
| TPK at admission | 0.3616 | NS |
| INR at admission | 0.4198 | NS |
| APTT at admission | 0.0020 | 0.060 |
| Platelet transfusion | 0.0030 | 0.054 |
| COX inhibitor treatment | 0.0176 | 0.034 |
| Radiologic intracranial hemorrhagic progression | 0.0001 | 0.104 |
Results from univariate analysis of independent variables assumed to affect Glasgow Outcome Scale (GOS) are depicted. Apart from the IMPACT variables (28), these comprised platelet count, coagulation measurements, variables hypothesized to modulate platelet function, and radiologic intracranial hemorrhagic progression. Platelet transfusion, COX inhibitor treatment, and radiologic intracranial hemorrhagic progression were used as dichotomous variables.
ADP, P2Y12 receptor; APTT, activated partial thromboplastin time; ASPI, arachidonic acid receptor; COX, cyclooxygenase; CT, computerized tomography; GCS, Glasgow Coma Scale; INR, international normalized ratio; SoA, scene of accident; TRAP, thrombin receptor.