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. 2018 Jan 30;9:327. doi: 10.1038/s41467-017-02395-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Antagonism between cancer and degenerative ageing diseases on the genetic level. a Shared synergistic and antagonistic risk SNPs between cancer and degenerative ageing diseases (DAD). “DAD total” indicates the total number of synergistic and antagonistic risk SNPs in the pairwise comparison between all three categories of degenerative ageing diseases. The total number of independent genomic loci in which the shared SNPs are contained is displayed on top of the bars. CVD cardiovascular diseases, NDD neurodegenerative diseases, T2D type 2 diabetes. b Randomization tests. Distributions depict the frequency at which the corresponding number of synergistic, antagonistic and total number of shared risk SNPs were encountered between cancer risk SNPs and randomly drawn risk SNPs from non-ageing-associated traits in 10,000 repetitions. Arrows indicate the actual observed number of antagonistic and total shared risk SNPs between cancer and degenerative ageing diseases. c Same as in b for degenerative ageing diseases instead of cancer