Classic Li–Fraumeni syndrome [3]	All of the following  Proband with sarcoma diagnosed before age 45 years  A first-degree relative with any cancer before 45 years  A first or second-degree relative with any cancer before 45 years or a sarcoma at any age
Li–Fraumeni-like syndrome—Birch [4]	All of the following  Proband with any childhood cancer, or a sarcoma, brain tumour or ACC with onset < 45 years  A first or second-degree relative with a core LFS cancer (sarcoma, breast cancer, brain tumour, ACC or leukaemia) with onset at any age  A first or second-degree relative with any cancer before age 60 years
Li–Fraumeni-like syndrome—Eeles [5]	Two first-degree or second-degree relatives with core LFS malignancies (sarcoma, premenopausal breast cancer, brain tumour ACC, leukaemia, lung [bronchoalveolar] cancer) at any age
Revised Chompret criteria [6]	Proband with a cancer belonging to the Li–Fraumeni spectrum before age 46 AND at least one first- or second-degree relative with a LFS tumour (except breast cancer if proband has breast cancer) before age 56 or with multiple tumours OR Proband with multiple tumours, two of which belong to LFS spectrum and first before age 46 years OR Proband with adrenocortical carcinoma or choroid plexus tumour, regardless of family history