Table 4.
Hazard ratios for mortality from baseline characteristics in patients with HeFREF, HeFNEF, and those without heart failure
| Cox regression | HeFREF N = 975 | HeFNEF N = 1040 | Not HF N = 873 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Variable | Hazard ratio representation | Hazard ratio (95% CI) | P value | Wald | Hazard ratio (95% CI) | P value | Wald | Hazard ratio (95% CI) | P value | Wald |
| Log[NT-ProBNP] | Per Log[NT-ProBNP] increase | 2.23 (1.78, 2.77) | < 0.001 | 50.27 | 2.12 (1.63, 2.75) | < 0.001 | 31.39 | 1.91 (0.98, 3.73) | 0.06 | 3.56 |
| Age | Per decade increase | 1.44 (1.26, 1.65) | < 0.001 | 28.01 | 1.69 (1.48, 1.95) | < 0.001 | 55.10 | 1.64 (1.33, 2.02) | < 0.001 | 21.58 |
| Diastolic BP | Per 5 mmHg increase | 0.91 (0.87, 0.95) | < 0.001 | 20.53 | 0.99 (0.95, 1.03) | 0.58 | 0.31 | 0.94 (0.87, 1.00) | 0.06 | 3.53 |
| NYHA | III/IV vs. I/II | 1.39 (1.12, 1.72) | 0.003 | 8.95 | 1.45 (1.15, 1.83) | 0.001 | 10.12 | 1.80 (1.19, 2.73) | 0.006 | 7.68 |
| Digoxin | Yes vs. no | 1.45 (1.02, 2.07) | 0.03 | 4.33 | 1.78 (1.17, 2.71) | 0.01 | 7.32 | 4.05 (1.67, 9.80) | 0.002 | 9.60 |
| eGFR | Per 5 mL/min/1.73 m2 increase | 0.97 (0.94, 1.00) | 0.03 | 4.67 | 0.99 (0.96, 1.02) | 0.43 | 0.62 | 0.99 (0.93, 1.05) | 0.66 | 0.19 |
| β-blocker | Yes vs. no | 0.85 (0.68, 1.07) | 0.16 | 1.97 | 0.82 (0.65, 1.03) | 0.09 | 2.87 | 0.61 (0.37, 1.00) | 0.05 | 3.84 |
| Loop diuretic | Yes vs. no | 1.21 (0.95, 1.55) | 0.13 | 2.30 | 1.69 (1.35, 2.11) | < 0.001 | 21.52 | 1.59 (1.12, 2.27) | 0.01 | 6.48 |
| Ischaemic heart disease | Yes vs. no | 1.17 (0.93, 1.46) | 0.17 | 1.85 | 0.90 (0.73, 1.12) | 0.34 | 0.90 | 1.17 (0.79, 1.72) | 0.44 | 0.60 |
| Body surface area | Per m2 increase | 0.62 (0.35, 1.10) | 0.10 | 2.69 | 0.52 (0.31, 0.87) | 0.01 | 6.08 | 0.75 (0.33, 1.67) | 0.47 | 0.51 |
| Sex | Men vs. women | 1.16 (0.90, 1.50) | 0.26 | 1.26 | 1.61 (1.27, 2.03) | < 0.001 | 15.70 | 2.17 (1.48, 3.21) | < 0.001 | 15.59 |
| Diabetes | Yes vs. no | 1.16 (0.90, 1.50) | 0.25 | 1.32 | 1.38 (1.08, 1.76) | 0.01 | 6.83 | 1.22 (0.77, 1.92) | 0.38 | 0.76 |
| PR | Per 10 ms increase | 1.01 (0.98, 1.05) | 0.40 | 0.70 | 0.99 (0.96–1.03) | 0.69 | 0.16 | 0.92 (0.85, 0.98) | 0.02 | 5.69 |
| Baseline heart rate | Per 10 beats per minute increase | 1.03 (0.96, 1.10) | 0.48 | 0.51 | 1.17 (1.08, 1.26) | < 0.001 | 15.12 | 1.17 (1.03, 1.33) | 0.02 | 5.42 |
| Amiodarone | Yes vs. no | 1.13 (0.71, 1.79) | 0.61 | 0.26 | 1.55 (0.84, 2.86) | 0.16 | 1.94 | 1.99 (0.60, 6.70) | 0.26 | 1.26 |
| QRS | Per 10 ms increase | 0.99 (0.96, 1.03) | 0.77 | 0.09 | 1.01 (0.96, 1.05) | 0.76 | 0.09 | 0.96 (0.86, 1.08) | 0.47 | 0.50 |
| CVA/TIA | Yes vs. no | 1.02 (0.71, 1.46) | 0.92 | 0.01 | 1.10 (0.77, 1.58) | 0.60 | 0.28 | 1.55 (0.79, 3.03) | 0.20 | 1.63 |
Bold indicates significance at the 0.05 level
Variables ranked by Wald score. Left ventricular dysfunction removed from model due to high correlation with NT-ProBNP
BP blood pressure, CVA/TIA cerebrovascular accident or transient ischaemic attack, DBP diastolic blood pressure; eGFR estimated glomerular filtration rate