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Homoplastic SNPs in drug resistance-associated genes. SNPs with FST in the top 1% of genome-wide values are labeled with the population (associated drug resistance) and the FST value. pncA is remarkable for harboring diverse homoplastic mutations, each of which occurs relatively infrequently (“sloppy target”). embB, gyrA, katG, rpoB, and rpsL harbor dominant mutations that occur frequently in the phylogeny and are strongly associated with resistant populations (“tight targets”).
