FIG 5 .

The microbiotas differ in the response and the relapse groups of CD patients treated with infliximab (IFX). The alpha diversity, measured by Shannon index (A) and PD whole tree (B), Clostridiales abundance (C), and calprotectin abundance (D), was restored in the response group after treatment compared to the relapse group. Stars (*) indicate P values of <0.05. (E and F) Supervised prognostic prediction of Crohn’s disease progression (IFX response or relapse). (E) The accuracy of prediction was best using the combination of microbiota, calprotectin, and CDAI (93.8%). The use of the microbiota alone (86.5%) still outperformed the results seen with the traditional clinic markers of CDAI (58.7%) or calprotectin (62.5%). (F) The top informative OTUs that contribute to the classification model. Clostridiales OTUs, colored in orange, are the most informative OTUs.