TABLE 2.

Twenty-five small molecules^a that inhibited both the E-S-FLU and H5-S-FLU viruses in this study

No. in Table S1	LOPAC plate no.	Sigma catalog no.	Name	Highest concn (μM) tested	IC50 (μM) for:		Effect
					E-S-FLU	H5-S-FLU
5	12-G4	O3125	Ouabain	1.5	0.28	0.3	Reduction
7	14-B2	R1402	Raloxifene HCl	50	0.40	33.8	Reduction
14	11-G7	N3510	Niclosamide	25	1.69	3.2	Reduction
21		U3633	U18666A	100	2.56	49.5	Reduction
27	04-B11	C8903	Clemastine fumarate salt	100	3.40	58.4	Reduction
35		SML0445	Clemastine	50	4.30	50.0	Reduction
42	04-F7	C6628	Chloroquine diphosphate	200	5.44	67.0	Reduction
48	03-B7	PZ0171	CP-100356 monohydrochloride	50	6.80	20.0	Reduction
54	02-H5	A9809	Amsacrine hydrochloride	25	7.68	6.76	Reduction
61	02-E10	A255	A-77636 hydrochloride	25	8.60	15.6	Reduction
63	08-E9	H127	Hexahydro-sila-difenidol hydrochloride, p-fluoro analog	100	9.30	65.0	Reduction
70	12-E7	L9793	LP44	100	10.40	70.0	Reduction
118	02-C7	PZ0178	PHA 767491 hydrochloride	25	21.30	15.7	Reduction
2	01-D5	A1784	Aminopterin	100	0.20	0.2	Dimmer
11	02-C11	SML0113	Brequinar sodium salt hydrate	100	1.30	1.4	Dimmer
19	04-D3	C3930	Calmidazolium chloride	6.25	2.30	3.9	Dimmer
20	03-D6	G6423	Gemcitabine hydrochloride	100	2.50	1.9	Dimmer
60	05-D6	D0670	Dihydroouabain	25	8.30	5.7	Dimmer
104	13-B10	SML0678	Pyridostatin trifluoroacetate salt	200	17.40	58.8	Dimmer
135	05-B9	D3768	Dequalinium chloride hydrate	100	27.30	12.1	Dimmer
145	14-C9	S3378	Spironolactone	100	30.40	33.1	Dimmer
159		2778-5b	Faviparivir (T705)	500	39.30	67.3	Dimmer
209	15-H7	T4143	Triamterene	200	85.20	132.3	Dimmer
222	15-A8	T4182	Tyrphostin AG 1478	200	115.30	141.0	Dimmer
226	14-C4	R9644	Ribavirin	200	125.20	125.9	Dimmer

^aTwenty-two are from the LOPAC¹²⁸⁰ library.

^bCambridge Biosciences.