FIG 7.

HDV, containing envelope proteins of different HBV genotypes, is susceptible to the inhibitory effect of NAPs. Huh-106 cells were inoculated with HDV virions (500 GE/cell) bearing the envelope proteins of the indicated HBV genotypes, or genotype D envelope proteins bearing the substitutions D144A or G145R, in the presence of 10 μM REP 2055 or REP 2172. Intracellular HDV RNA extracted at 9 dpi was quantified by Northern blot analysis for measurement of infection. Values in the histograms are shown as percent infection (mean ± SD) in the presence of REP 2172 control, obtained in three independent experiments.