TABLE 1.

Sequences and chemical properties of the NAPs used in this study^a

NAP	Sequence	Length (nt)	PS	2′OMe	5-MeC
REP 2006	dN40	40	+
REP 2031	dC40	40	+
REP 2181	(dAdC)50	100	+
REP 2180	(dAdC)40	80	+
REP 2149	(dAdC)30	60	+
REP 2055	(dAdC)20	40	+
REP 2150	(dAdC)15	30	+
REP 2151	(dAdC)10	20	+
REP 2152	(dAdC)5	10	+
REP 2107	N40	40	+	+
REP 2138	C40	40		+
REP 2139	(AC)20	40	+	+	+
REP 2165	(AC)20	40	+	+b	+
REP 2147	(AC)20	40		+	+
REP 2172	(AC)20	40		+

^aAbbreviations: d, DNA; N, degenerate sequence; PS, phosphorothioation of phosphodiester linkage (increases amphipathicity); 2′OMe, O-linked methylation at the 2′ position in ribose (increased stability and reduced Toll-like receptor [TLR] reactivity); 5-MeC, methylation at the 5′ position in cytidine base (reduced TLR reactivity).

^bPositions 11, 21, and 31 have 2′OH ribose.