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. 2018 Jan 30;92(4):e01588-17. doi: 10.1128/JVI.01588-17

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FIG 6 — N9 MAbs inhibit the NAs of viruses resistant to antivirals. (A) NA activity of H6N9_AH/13 viruses with antiviral-resistant mutations E119V, I222R, A246T, and R292K in the NA, measured by MU-NANA assay with viruses incubated with the substrate for 1 h (left panel) and 3.5 h (center panel) or with a low-pH (5.3) buffer (right panel). RFU, relative fluorescence units. Data represent the means plus standard deviations of two independent assays run in duplicate. (B) Plaques of H6N9_AH/13 mutant viruses in MDCK cells cultured at 33°C (upper panel) and 37°C (lower panel). (C) Plaque sizes of the H6N9_AH/13 mutant viruses described in panel B. *, P < 0.05. (D) Plaques of H6N9_AH/13 mutant viruses in MDCK cells cultured in the presence of N9 MAbs 1E8, 2F6, 10F4, and 11B2 and the control MAb 3A2 in the agar overlay. 1E8, 11B2, and 3A2 were supplemented at 5 μg/ml, whereas 2F6 and 10F4 were supplemented at 1 μg/ml.