FIG 7.

N9 MAbs vary in protecting mice from lethal A(H7N9) virus challenge. BALB/c mice (n = 10 per group) were treated i.p. with MAbs at 0.5 or 5 mg/kg, followed by i.n. challenge with 10 MLD₅₀ of wt AH/13 12 h later. The N1-specific MAb 3A2 was administered at 5 mg/kg as a negative control. Survival and weight loss (n = 5 per group) were monitored for 14 days. Lungs from another five mice were collected on day 6 p.c. for virus titration (n = 3) and histological examination (n = 2) (Fig. 8). (A) Survival and weight loss. (B) Lung virus titers expressed as log₁₀ PFU/g. Data are the means plus standard deviations (n = 3). *, P < 0.05.