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. 2018 Jan 30;92(4):e01885-17. doi: 10.1128/JVI.01885-17

FIG 4.

FIG 4

Reduction of HTLV-1-infected Env-expressing target cells by superinfection with rVSVs. (A) The expression level of HTLV-1 Env was analyzed in various HTLV-1-infected or uninfected cell lines. HTLV-1-infected TL-Om1, HUT-102, SLB-1, MT-2, or ATL-056i cells and uninfected Jurkat, MOLT-4, or Raji cells were stained with mouse anti-HTLV-1 gp46 MAb or mouse IgG1 MAb as an isotype control. The stained cells were subjected to flow cytometry. The percentages of HTLV-1 gp46-positive cells are presented in each panel. (B) Results from evaluation of rVSV-mediated killing effects on various HTLV-1-infected or uninfected cell lines are shown. The cell lines described above were infected with G-complemented VSVΔG, VSVΔG-GL, VSVΔG-NP, VSVΔG-SD, VSVΔG-GLN, or VSVΔG-GLNS (MOI of 0.1) or without rVSV (mock) for 14 days. The numbers of viable cells were counted at days 4, 7, 10, and 14 after rVSV infection. Data obtained from triplicate cultures are expressed as the mean ± SD (×104/ml).