FIG 10.

Relationships between species-specific glycan expression and glycan recognition by lagoviruses. Expression of glycans in the trachea is shown for each host species (A, B, H, and GlcNAc). The arrows indicate glycan recognition of each virus, with thicker arrows showing preferred recognition. The dashed arrow indicates acquisition of A antigen recognition by GI.1 through coevolution with O. cuniculus (nonpathogenic GI viruses are similar to late GI.1 that binds A antigen). The broad HBGA specificity of GI.2 may contribute to explaining its wider host range and ability to replace GI.1 strains, while conversely, the unique restricted specificity of GII.1 for N-acetylglucosamine (GlcNAc) is associated with its limited host range.