TABLE 1.

Summary of neutralization observed for the PfTrx–8-mer–OVX313 antigen in mice and/or guinea pigs

HPV type(s)	Assay or model with animalc:					Contribution (%) to:
	In vitro PBNA				In vivo passive transfer mouse model
	Mouse		Guinea pig
	L1	L2	L1	L2		Cervical carcinomaa	Genital wartsb
16	+++	+++	+++	+++	+++	53.5	0
18	+++	NT	+++	+++	+++	17.2	0
45	+++	NT	+++	+++	+++	6.7	0
31	+++	NT	+++	+++	+++	2.9	0
33	+++	NT	+++	+++	+++	2.6	0
52	++	NT	++	+++	NT	2.3	0
58	+++	NT	+++	+++	+++	2.2	0
35	+++	NT	+++	+++	+++	1.4	0
59	+++	NT	+++	+++	NT	1.3	0
56	−	+++	+++	+++	++	1.2	0
51	+++	NT	+++	+++	NT	1.0	0
39	+	+++	+++	+++	+++	0.7	0
68	++	+++	++	+++	NT	0.6	0
73	+++	NT	+++	+++	NT	0.5	0
82	NT	NT	NT	NT	NT	0.3	0
40, 42, 53, 54, 55, 83, 84	NT	NT	NT	NT	NT	1.2	0
Untyped HPV	NT	NT	NT	NT	NT	4.4	0
6	+++	NT	+++	+++	++	0	74
11	+++	NT	+++	+++	++	0	14

^aData from reference 1.

^bData from reference 52.

^cSymbols and abbreviations: NT, not tested; −, not reactive; +, 1 to 3 mice out of 10 showed a response; ++, 4 to 7 mice out of 10 showed a response; +++, 8 to 10 mice out of 10 showed a response.