TABLE 1.

N1-7D3 epitope percent residue conservation in human, avian, and swine N1 viruses

Virusa	% conservation at residueb:
	W457	P458	D459	G460	A461	E462	D462	L463	P464	F465	T466	I467	D468	K469
Human H1N1 pre-2009	100	100	100	99.5	99.9	98.8	1.2	99.8	99.9	99.6	98.4	99.7	99.8	99.8
A(H1N1)pdm09	99.8	99.8	99.9	100	100	99.7	0.04	99.6	99.9	99.9	98.5	97.8	99.8	98.4
Avian H*N1	99.8	99.7	99.7	99.5	99.8	99.5	0.43	97.5	100	99.7	98.8	99.2	99.7	99.3
Swine H*N1	99.9	99.9	99.8	100	99.2	42.4	54.5	99.7	100	99.8	92.3	96.8	99.4	99.6

^aSequences were downloaded from the influenza virus NCBI database and aligned with ClustalO (54). Percent conservation was determined using the online software ConSurf (55).

^bHuman N1 numbering.