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Residues identified in escape mutant selectiona
| Escape mutant | Mutation |
|---|---|
| 1 | E311D |
| 2 | E311K |
| 3 | K260E/E311K |
| 4 | S266A/S364G |
| 5 | S266A/E311K |
Bel/09 was selected for resistance against N1-C4. Resistant viruses were identified via escape in a plaque reduction assay where the NA was cloned into pBluescript and sequenced to determine mutations.
