Table 1.
Characteristics of the subjects at baseline (full analysis set)
| Characteristic | Arm 1, n=113 | Arm 2, n=34 | Arm 3, n=34 | Arm 4, n=116 | Arm 5, n=104 |
|---|---|---|---|---|---|
| Age, yr | |||||
| Median | 74.0 | 71.0 | 75.0 | 75.0 | 71.5 |
| Interquartile range | 65–80 | 62–77 | 67–79 | 67–78 | 64–77 |
| Women, no. (%) | 44 (38.9) | 15 (41.1) | 12 (35.3) | 38 (32.8) | 33 (31.7) |
| Race,a no. (%) | |||||
| White | 103 (91.2) | 30 (88.2) | 32 (94.1) | 107 (92.2) | 94 (90.4) |
| Black | 5 (4.4) | 3 (8.8) | 0 | 5 (4.3) | 3 (2.9) |
| Other | 5 (4.5) | 1 (2.9) | 2 (5.8) | 4 (3.5) | 7 (6.7) |
| Body mass indexb | |||||
| Median | 28.3 | 30.4 | 28.7 | 28.1 | 28.3 |
| Interquartile range | 26–33 | 24–35 | 26–33 | 26–32 | 26–33 |
| GFR,c ml/min per 1.73 m2 | |||||
| Median | 59.5 | 62.8 | 61.2 | 61.3 | 63.6 |
| Interquartile range | 44–79 | 47–79 | 48–75 | 48–76 | 48–83 |
| Medical history,d no. (%) | |||||
| CKD | 42 (37.2) | 19 (55.9) | 15 (44.1) | 44 (37.9) | 40 (38.5) |
| AKI | 23 (20.4) | 7 (20.6) | 10 (29.4) | 20 (17.2) | 28 (26.9) |
| Hypertension | 83 (73.5) | 24 (70.6) | 24 (70.6) | 105 (90.5) | 88 (84.6) |
| Cardiac failure | 49 (43.4) | 17 (50.0) | 18 (52.9) | 47 (40.5) | 55 (52.9) |
| Ischemic heart disease | 86 (76.1) | 28 (82.4) | 26 (76.5) | 91 (78.4) | 80 (76.9) |
| Cardiac arrhythmia | 48 (42.5) | 17 (50.0) | 9 (26.5) | 50 (43.1) | 39 (37.5) |
| Cerebrovascular disorder | 19 (16.8) | 7 (20.6) | 5 (14.7) | 26 (22.4) | 23 (22.1) |
| Diabetes mellitus | 60 (53.1) | 18 (52.9) | 16 (47.1) | 55 (47.4) | 51 (49.0) |
Arm 1 indicates placebo. Arm 2 =0.02-mg/kg preoperative and postoperative doses. Arm 3 =0.12-mg/kg preoperative and 0.02-mg/kg postoperative doses. Arm 4 =0.46-mg/kg preoperative and 0.02-mg/kg postoperative doses. Arm 5 =0.46-mg/kg preoperative and postoperative doses.
Race was self-reported.
The body mass index is the weight in kilograms divided by the square of the height in meters.
The GFR was estimated using the four-variable Modification of Diet in Renal Disease formula.
These data were derived from the clinical database using narrow Standardized Medical Dictionary for Regulatory Activities Queries. AKI was collected using the renal failure query, cerebrovascular disorders were collected using the cerebrovascular nervous system disorders query, and diabetes mellitus was collected using the hyperglycemia/new-onset diabetes mellitus query.