Table 1.

Demographic and immunopathologic characteristics of the patients of the GEMRITUX cohort, according to therapeutic intervention at M0, M3, and M6

Characteristics	Whole Cohort, n=58	NIAT, n=29	RITUX, n=29	P Value
Age	56.5 [42.0–63.0]	59.0 [44.0–63.0]	52.0 [41.0–63.0]	0.5
Sex				0.4
Men	42 (72.4)	19	23
Women	16 (27.6)	10	6
Proteinuria at M0, g/g of serum creatinine	8.2 [4.8–10.0]	7.4 [6.2–9.0]	8.4 [4.4–11.0]	0.51
Serum albumin at M0, g/dl	2.2 [1.9–2.5]	2.2 [2.0–2.5]	2.2 [1.8–2.5]	0.52
Serum creatinine at M0, mg/L	10.8 [9.0–13.8]	10.4 [8.7–13.8]	11.5 [9.4–13.1]	0.48
PLA2R1-Ab at M0, RU/ml	101.5 [31.2–481.2]	199.5 [24.2–480.0]	100.5 [35.4–481.2]	0.85
CysR at M0, RU/ml	1423.5 [369.0–3240.0]	1572.0 [494.0–3240.0]	1256.0 [270.0–3114.0]	0.52
CTLD1 at M0, RU/ml	157.0 [0.0–2334.0]	12.0 [0.0–1190.0]	471.0 [0.0–2334.0]	0.33
CTLD7 at M0, RU/ml	220.5 [23.0–609.0]	136.0 [36.0–662.0]	223.0 [13.0–604.0]	0.65
Group M0				0.74
CysR	20 (34.48)	11 (37.93)	9 (31.03)
CysRC1	8 (13.79)	4 (13.79)	4 (13.79)
CysRC7	10 (17.24)	6 (20.69)	4 (13.79)
CysRC1C7	20 (34.48)	8 (27.59)	12 (41.38)
Spreading M0	38/58 (65.6)	18 (62.1)	20 (68.9)	0.78
Proteinuria at M3, g/g of serum creatininea	5.1 [3.2–7.6]	5.0 [3.0–8.5]	5.1 [3.5–7.4]	0.86
Serum albumin at M3, g/dlb	2.6 [2.0–2.9]	2.3 [1.8–2.7]	2.7 [2.1–3.1]	0.12
Serum creatinine at M3, mg/La	11.5 [9.4–13.6]	11.5 [9.7–13.9]	11.8 [9.0–13.6]	0.99
PLA2R1-Ab at M3, RU/mlc	43.1 [0–102.5]	70.5 [30.3–325.9]	0.0 [0.0–60.5]	0.002
Group M3d				0.002
Negative	12 (24.5)	0 (0.0)	12 (46.2)
CysR	10 (20.4)	7 (30.4)	3 (11.5)
CysRC1	9 (18.4)	6 (26.1)	3 (11.5)
CysRC7	6 (12.2)	3 (13.1)	3 (11.5)
CysRC1C7	12 (24.5)	7 (30.4)	5 (19.2)
Spreading M3d	27/49 (55.1)	16 (69.6)	11 (42.3)	0.09
Proteinuria at M6, g/g of serum creatininee	4.4 [2.0–7.3]	6.2 [2.2–7.5]	3.7 [1.8–6.5]	0.21
Serum albumin at M6, g/dle	2.6 [2.1–3.3]	2.4 [2.0–2.9]	2.9 [2.5–3.4]	0.07
Serum creatinine at M6, mg/Le	11.9 [9.4–14.8]	12.0 [9.4–14.4]	11.9 [9.8–14.8]	0.71
PLA2R1-Ab at M6, RU/mlf	30.1 [0–98.5]	57.2 [16.5–298.0]	0 [0–57.0]	0.01
Group M6c
Negative	17 (34.0)	0 (0.0)	17 (65.4)
CysR	14 (28.0)	12 (50.0)	2 (7.7)	<0.001
CysRC1	5(10.0)	4 (16.7)	1 (3.9)
CysRC7	2 (4.0)	2 (8.3)	0 (0.0)
CysRC1C7	12 (24.0)	6 (25.0)	6 (23.1)
Spreading M6c	19/50 (38.0)	12/24 (50.0)	7/26 (26.9)	0.15

Data are shown as n (%) or median [interquartile range].

^aOne missing value.

^bTwo missing values.

^cEight missing values.

^dNine missing values.

^eFour missing values.

^fFive missing values.