Table 5.
Predicted activity of upstream regulators in tolerant FCRx samples versus D biopsies
| Upstream Regulator | Predicted Activity | Activation z Score | P Value of Overlap |
|---|---|---|---|
| MYD88 | Inhibited | −2.952 | <0.001 |
| EGF | Inhibited | −2.930 | <0.001 |
| TLR3 | Inhibited | −2.574 | <0.001 |
| TNF | Inhibited | −2.244 | <0.001 |
| IL13 | Inhibited | −2.003 | 0.002 |
| TLR9 | Inhibited | −2.397 | 0.002 |
| PTGS2 | Inhibited | −2.540 | 0.003 |
| NF-kB (complex) | Inhibited | −2.132 | 0.003 |
| GDNF | Inhibited | −2.182 | <0.01 |
| PDGF BB | Inhibited | −2.397 | <0.01 |
| SFTPA1 | Activated | 2.236 | <0.01 |
| CD24 | Activated | 2.000 | <0.01 |
| Tlr | Inhibited | −2.408 | 0.01 |
| TLR4 | Inhibited | −2.236 | 0.01 |
| ERK | Inhibited | −2.275 | 0.01 |
| IGF1 | Inhibited | −3.333 | 0.02 |
| FOSL1 | Activated | 2.000 | 0.02 |
| Cg | Inhibited | −2.227 | 0.03 |
| Creb | Inhibited | −2.156 | 0.03 |
| TLR2 | Inhibited | −2.195 | 0.03 |
| EGFR | Inhibited | −2.746 | 0.04 |
| PI3K (complex) | Inhibited | −2.014 | 0.04 |
| IRF8 | Inhibited | −2.195 | 0.05 |