. Author manuscript; available in PMC: 2018 Jan 31.

Published in final edited form as: Nat Med. 2016 Oct 26;22(11):1239–1247. doi: 10.1038/nm.4218

Table 1.

Overview of studies correlating neurogenesis in the DG and neuropsychiatric disorders. Given that more than 2,000 publications have contributed to the correlative findings summarized here, review publications are primarily cited in Table 1 to direct the reader to comprehensive and referenced tables in the literature

Correlated with neuropsychiatric disorders	Stage of neurogenesis (human postmortem)			Hippocampal		Normalize/improve with treatment? (human/rodents)
Correlated with neuropsychiatric disorders	Proliferation	Differentiation	Survival	Volume (human)	Network activity (human/rodents)	Normalize/improve with treatment? (human/rodents)
Major depressive disorder	Decreased/nc^133–135	–	Decreased*¹⁰⁴	Decreased¹³⁶	Decreased^59,61	✓/nc^{42,97,104,133,134}
Bipolar disorder	nc¹³⁵	Increased¹²⁵	Decreased (trend)¹²⁵	Decreased/nc^137,138	Decreased/Increased/nc¹³⁹	✓^99,140,141
Schizophrenia	Decreased^132,135	Decreased¹⁴²	–	Decreased¹⁴³	Increased/Decreased^92,93,144	✓¹⁰¹
Post-traumatic stress disorder	–	–	–	Decreased¹⁴⁵	Decreased⁹⁴	✓¹⁰⁰
Substance-related and addictive disorder	Decreased¹⁴⁶	Decreased^#¹⁴⁶	–	Decreased/nc^147,148	Increasedˆ⁹⁵	✓⁴¹

Asterisk (*), fewer DG granule neurons in MDD versus MDD with medication and controls;

decreased dendritic arborization of immature neurons in heroin addicts;

carat (ˆ), increased connectivity between hippocampus and reward-related brain regions. nc, not changed;

dash (–), not studied.