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. 2018 Jan 30;15:6. doi: 10.1186/s12979-017-0110-7

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Analysis of the TNF-α, IL-6, IL-1β mRNA expression levels in mice brain tissues by qRT-PCR. (a) the mRNA expression of TNF-α in middle-aged P. gingivalis infected mice was increased; (b) P. gingivalis infection increased the mRNA levels of IL-6 in middle-aged mice; (c) the mRNA expression levels of IL-1β were increased in middle-aged P. gingivalis infected mice when compared to the control group. “**” indicates statistical significant difference (P < 0.01) between P. gingivalis infected mice and the corresponding control group