Fig. 2.

Aged mice are more susceptible to memory impairments after SI. a SI induced depressive-like behavior in both young and aged mice (n = 10 per group, from two independent experiments). b Object recognition test showed that SI affected short-term memory of aged mice only (aged SI). Statistical analysis two-tail univariate T test (N = 14–24 per group, from three independent experiments; # not statistically different from 50%). c Learning curves of mice for hidden platform water maze test were not significantly altered by age or SI. d Swimming velocity on the test day was not significantly affected by age or by SI. e Time in the target platform was significantly decreased in aged mice after SI on day 5. Each test was performed at least three times with different sets of mice. Figures show a representative water maze experiment. Data were plotted as means ± SEM (N = 10 to 13 per group). Statistical analysis with two-way ANOVA and Bonferroni posttest (*P < 0.05)