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. 2018 Jan 30;15:28. doi: 10.1186/s12974-018-1059-y

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Brain cytokines levels long term after episodic inflammation. Brain cytokines IL-1ß (a), IL-6 (b), IL-4 (c), and IL-10 (d) were measured in young and aged mice naïve (control) and after episodic systemic inflammation (SI). All cytokines measured were significantly elevated in the brains of aged mice after SI. Data were plotted as means ± SEM (N = 8 per group, samples collected from 3 independent experiments). Statistical analysis with two-way ANOVA with Bonferroni posttest (*P < 0.05, **P < 0.01, ***P < 0.001)