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. 2018 Jan 30;15:28. doi: 10.1186/s12974-018-1059-y

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Overview of the effect of episodic systemic inflammation and aging on microglia. Young microglia have highly branched processes and are responsive to stimuli, contributing to tissue homeostasis. Aged microglia are dystrophic and resistant to regulation. Episodic systemic inflammation contributed to age-related microglia phenotype that was associated with age-related cognitive impairments