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. 2018 Jan 30;18:39. doi: 10.1186/s12906-017-2058-8

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Inhibitory activity of hesperidin on the UVB-induced MMP-9 protein expression and enzyme activity in the photoaged hairless mice model. (a) Inhibition of the UVB-induced MMP-9 protein expression by hesperidin. The MMP-9 levels were determined by western blotting analysis. (b) The mRNA MMP-9 levels were determined by RT-PCR. (c) Inhibition of MMP-9 activity was measured by gelatin zymography. #P < 0.05 significant difference from control and *P < 0.05 significant difference from UVB/vehicle groups