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. 2018 Jan 31;25:8. doi: 10.1186/s12929-018-0409-5

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — a Line graph shows the time course of percentage changes in MAP (left) and HR (right) after ICV injection of different doses of NPLA, a nNOS inhibitor (n = 4 each). The average BP and HR 60 min before NPLA injection are taken as baseline (b) of 100%. b Line graph show time course of percentage change in MAP (left) and HR (right) after administration of ethanol (3.2 g/kg) with or without ICV treatment with 10 nmol NPLA (n = 4) on day 1 treatment of ethanol. NPLA was given immediately after ethanol administration. The average BP and HR 60 min before ethanol administration are taken as baseline (b) of 100%. *P < 0.05 compared with baseline (b) using repeated measure one-way ANOVA followed by Dunnett’s post-test. #P < 0.05 compared with ethanol group analyzed by repeated measure two-way ANOVA followed by Bonferroni post-test