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. 2018 Jan 31;25:8. doi: 10.1186/s12929-018-0409-5

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — a Line graph shows the time course of percentage changes in MAP (left) and HR (right) after ICV injection of different doses of NOC-18, an 00000NO donor (n = 3 each). The average BP and HR 60 min before NOC-18 injection are taken as baseline (b) of 100%. *p < 0.05 compared with baseline using repeated measure one way ANOVA followed by Dunnett’s posttests. b Line graph show time course of percentage change in MAP (left) and HR (right) after administration of ethanol with or without ICV treatment with 12 nmol NOC-18 (n = 4) on day 8 treatment of ethanol. NOC-18 was given immediately after ethanol administration. The average BP and HR 60 min before ethanol administration are taken as baseline (b) of 100%. #P < 0.05 compared with no ICV treatment using repeated measure two-way ANOVA followed by Bonferroni post-test