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. 2018 Jan 30;12:4. doi: 10.1186/s12918-018-0525-6

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License(http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — a Minimal model of NFκB signaling networks and the therapeutic strategy of NFκB synthetic decoy ODNs. Protein-binding Microarrays (PBMs) experiments indicate that the unbinding rates of genomic decoy sites (indicated in Fig. 1. as Decoy _1, 2…) follow a distribution plotted in Fig. 1a. b Oscillatory temporal dynamics of nuclear free NFκB and inhibitory effect of synthetic decoy ODNs