Fig. 3.

a Time courses of NFκB synthetic decoy ODNs and nuclear free NFκB concentrations under different degradation rates (λ_s=0.001,0.005,0.02min⁻¹) of synthetic decoy ODNs, under conditions of both no molecular stripping (k_s=0 μM⁻¹min⁻¹) and with molecular stripping (k_s=10 μM⁻¹min⁻¹). Unbinding rate of synthetic decoy ODNs is set to k_soff=1 min⁻¹. b Time courses of NFκB synthetic decoy ODNs and nuclear free NFκB concentrations under different degradation rates (λ_s=0.001,0.005,0.02 min⁻¹) of synthetic decoy ODNs, under conditions of both no molecular stripping (k_s=0 μM⁻¹min⁻¹) and with molecular stripping (k_s=10 μM⁻¹min⁻¹). Unbinding rate of synthetic decoy ODNs is set to k_soff=0.02 min⁻¹. The red arrows indicate the duration of action, during which the concentration of nuclear free NFκB does not exceed 0.1 μM