Fig. 5.

a Duration of Action as a function of nuclease-induced degradation rate (λ_s) with different unbinding rates (k_soff=0.02,0.2,1 min⁻¹), under no molecular stripping (k_s=0 μM⁻¹min⁻¹) and with molecular stripping (k_s=10 μM⁻¹min⁻¹).Dose of NFκB synthetic decoy ODNs is set to be 1 μM. b Duration of Action as a function of dose of NFκB synthetic decoy ODNs under different degradation rates (λ_s=0.001,0.005,0.02 min⁻¹), under slow unbinding rate (k_soff=0.02 min⁻¹) and fast unbinding rate (k_soff=1 min⁻¹), under no molecular stripping (k_s=0 μM⁻¹min⁻¹) and with molecular stripping (k_s=10 μM⁻¹min⁻¹)