Figure 5.

Curcumol decreases CSLCs self-renewal in vivo. (A) Tumor-bearing nude mice were treated with (200 mg/kg/day) orally for 10 days when the tumor grew to 100 mm³. Subcutaneous tumor in DMSO group vs. curcumol group of nude mice. (B) Tumor volumes were measured every 4 days for 3 weeks (DMSO vs. curcumol group). (C) Tumor weight in the indicated mice (DMSO vs. curcumol group). (D) IHC staining displaying the DNMT1, DNMT3b, HDAC1, and HDAC3 protein expression between DMSO and curcumol groups (IHC, 40×). (E) Kaplan-Meier curves of mice with curcumol treatment, compared with the DMSO group. Data represent mean ±SD from at least 3 independent experiments, ** p<0.01; *** p<0.001.