Table III.
Immunohistochemical characteristics of the 81 early gastric carcinoma cases.
| Mucosal region, immunohistochemical score [n (%)] | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Normal mucosa | Metaplastic mucosa | Tumor | ||||||||||||||||
| Antibody and Lauren classification | 0 | 1+ | 2+ | 3+ | 4+ | P-value | 0 | 1+ | 2+ | 3+ | 4+ | P-value | 0 | 1+ | 2+ | 3+ | 4+ | P-value |
| p16ink | 0.66 | 0.13 | 0.9 | |||||||||||||||
| Intestinal | 19 (51.4) | 13 (35.1) | 4 (10.8) | 1 (2.7) | 0 (0.0) | (n=67) | 2 (6.1) | 13 (39.4) | 2 (6.1) | 7 (21.2) | 9 (27.3) | (n=56) | 6 (20.0) | 4 (13.3) | 4 (13.3) | 4 (13.3) | 11 (33.7) | (n=57) |
| Diffuse | 12 (57.1) | 5 (23.8) | 3 (14.3) | 0 (0.0) | 1 (4.8) | 1 (6.7) | 5 (33.3) | 4 (26.7) | 3 (20.0) | 2 (13.3) | 1 (5.6) | 4 (22.2) | 4 (22.2) | 3 (16.7) | 6 (33.3) | |||
| Mixed | 5 (55.6) | 2 (22.2) | 1 (11.1) | 1 (11.1) | 0 (0.0) | 2 (25.0) | 0 (0.0) | 3 (37.5) | 1 (12.5) | 2 (25.0) | 1 (11.1) | 2 (22.2) | 2 (22.2) | 1 (11.1) | 3 (33.3) | |||
| p53 | 0.77 | 0.35 | 0.5 | |||||||||||||||
| Intestinal | 15 (40.5) | 16 (43.2) | 5 (13.5) | 1 (2.7) | 0 (0.0) | (n=66) | 3 (9.7) | 13 (41.9) | 12 (38.7) | 3 (9.7) | 0 (0.0) | (n=55) | 0 (0.0) | 3 (9.1) | 12 (36.4) | 10 (30.3) | 8 (24.2) | (n=62) |
| Diffuse | 5 (23.8) | 11 (52.4) | 4 (19.0) | 1 (4.8) | 0 (0.0) | 3 (20.0) | 9 (60.0) | 1 (6.7) | 1 (6.7) | 1 (6.7) | 0 (0.0) | 3 (15.8) | 2 (10.5) | 9 (47.4) | 5 (26.3) | |||
| Mixed | 2 (25.0) | 4 (50.0) | 1 (12.5) | 1 (12.5) | 0 (0.0) | 1 (11.1) | 5 (55.6) | 3 (33.3) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 2 (20.0) | 2 (20.0) | 3 (30.0) | 3 (30.0) | |||
| p27ras | 0.048 | 0.26 | 0.4 | |||||||||||||||
| Intestinal | 7 (18.9) | 23 (62.2) | 7 (18.9) | 0 (0.0) | 0 (0.0) | (n=68) | 3 (9.5) | 27 (84.4) | 2 (6.3) | 0 (0.0) | 0 (0.0) | (n=57) | 1 (3.1) | 10 (15.9) | 19 (59.4) | 2 (6.3) | 0 (0.0) | (n=63) |
| Diffuse | 3 (13.6) | 19 (86.4) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 2 (12.5) | 14 (87.5) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (4.8) | 8 (38.1) | 8 (31.2) | 4 (19.0) | 0 (0.0) | |||
| Mixed | 0 (0.0) | 9 (100.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 3 (33.3) | 5 (55.6) | 1 (11.1) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 5 (50.0) | 5 (50.0) | 0 (0.0) | 0 (0.0) | |||
| p27kip1 | 0.28 | 0.3 | 0.038 | |||||||||||||||
| Intestinal | 13 (37.1) | 14 (40.0) | 7 (20.0) | 1 (2.9) | 0 (0.0) | (n=68) | 1 (3.1) | 6 (18.8) | 14 (43.8) | 9 (28.1) | 2 (6.3) | (n=57) | P=0.3 | 3 (8.8) | 11 (32.4) | 15 (44.1) | 2 (5.9) | (n=64) |
| Diffuse | 10 (45.5) | 8 (36.4) | 4 (18.2) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 4 (25.0) | 9 (56.3) | 2 (12.5) | 1 (6.3) | 0 (0.0) | 4 (19.0) | 3 (14.3) | 8 (38.1) | 6 (28.6) | |||
| Mixed | 3 (33.3) | 3 (33.0) | 1 (11.1) | 1 (11.1) | 1 (11.1) | 2 (22.2) | 1 (11.1) | 4 (44.4) | 2 (22.2) | 0 (0.0) | 0 (0.0) | 0 | 6 (66.7) | 2 (22.2) | 1 (11.1) | |||
| p21waf1/cip1 | 0.6 | 0.5 | 0.034 | |||||||||||||||
| Intestinal | 28 (76.0) | 6 (16.0) | 3 (8.0) | 0 (0.0) | 0 (0.0) | (n=68) | 9 (28.0) | 6 (19.0) | 7 (22.0) | 6 (19.0) | 4 (12.0) | (n=55) | 10 (29.4) | 8 (23.5) | 15 (44.1) | 1 (2.9) | 0 (0.0) | (n=63) |
| Diffuse | 13 (59.0) | 07 (32.0) | 2 (9.0) | 0 (0.0) | 0 (0.0) | 2 (13.0) | 4 (27.0) | 4 (27.0) | 3 (20.0) | 2 (13.0) | 8 (40.0) | 7 (35.0) | 2 (10.0) | 2 (10.0) | 1 (5.0) | |||
| Mixed | 5 (56.0) | 3 (33.0) | 1 (11.0) | 0 (0.0) | 0 (0.0) | 4 (50.0) | 0 (0.0) | 3 (37.0) | 1 (12.0) | 0 (0.0) | 0 (0.0) | 5 (55.6) | 2 (22.2) | 2 (22.2) | 0 (0.0) | |||