Skip to main content
. 2016 Jun 13;18(12):1634–1643. doi: 10.1093/neuonc/now114

Fig. 4.

Fig. 4.

Preservation of VEP responses in CNF1-treated glioma-bearing mice. (A) Transient VEP amplitude in naïve, vehicle (Veh), and CNF1 glioma-bearing mice. Representative waveforms from each group are shown on top. Responses in vehicle-treated mice (n = 7) are consistently lower compared with CNF1-treated glioma mice (n = 6) and naïve animals (n = 6; 1-way ANOVA followed by Holm–Sidak test, P < .05). Data are mean ± SEM. *P < .05. (B) Latency of transient VEPs in naïve, vehicle-, and CNF1-injected glioma-bearing mice. There are no statistical differences among groups (1-way ANOVA, P = .175). Data are mean ± SEM. (C) Amplitude of steady-state VEPs is plotted as a function of variable contrast (10%, 20%, 30%, 90%) in control and GL261-injected mice. Noise level (dotted line) represents the response to a blank stimulus (0% contrast). VEP responses are strongly reduced in vehicle glioma-bearing mice with respect to both naïve and CNF1-infused animals (2-way repeated measures ANOVA followed by Holm–Sidak test). Naïve, n = 6; vehicle-treated glioma-bearing mice, n = 7; CNF1-treated glioma-bearing mice, n = 6. Data are mean ± SEM. *P < .05, **P < .01.