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. Author manuscript; available in PMC: 2018 Jan 31.
Published in final edited form as: Chem Rev. 2015 Aug 10;115(19):10690–10724. doi: 10.1021/cr500698d

Figure 17. MNP surface conjugation chemistries.

Figure 17

(a) Schematic illustration of covalent conjugation strategies, including amine, carboxylic acid, and sulfhydryl reactive chemistries. (b) Representative bioorthogonal covalent conjugation chemistries. CuAAC, Cu(I)-mediated [3 + 2] azide-alkyne cycloaddition; Tz, teterazine; and TCO, trans-cyclooctene. (c) The schematics of the bioorthogonal nanoparticle detection (BOND) technique, which utilizes Tz-TCO cycloaddition as the conjugation mechanism. Antibodies are modified with TCO and used as scaffolds to label more Tz modified MNPs onto target cells.