Table 5.

Selected nonneoplastic and neoplastic nasal cavity, thyroid, lung, or forestomach lesions from the 2-year N,N-dimethyl-p-toluidine studies in F344/N rats and/or and B6C3F1 mice.^#

Dose (mg/kg)	0	6	20	60
Male rats—nasal cavity
Transitional epithelium—adenoma	0**	3	2	11**
Transitional epithelium—carcinoma	0*	0	0	2
Transitional epithelium—adenoma or carcinoma	0**	3	2	13**
Glands, olfactory epithelium—adenoma	0	0	0	1
Female rat—nasal cavity
Transitional epithelium—adenoma	0	1	0	2
Male rats thyroid
Follicular cell—adenoma or carcinoma	1	2	2	4
Female mice—lung
Alveolar/bronchiolar adenoma or carcinoma	2**	5	9*	13**
Female mouse—forestomach
Squamous cell papilloma or carcinoma	1	6	6*	7*

N = 49 to 50.

Note.

^#Pairwise statistic is under the N,N-dimethyl-p-toluidine (DMPT) dose group columns; trend statistic is under the control column.

^*p ≤ .05.

^**p ≤ .01.