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. Author manuscript; available in PMC: 2018 Jan 31.
Published in final edited form as: Toxicol Lett. 2016 Nov 30;266:32–41. doi: 10.1016/j.toxlet.2016.11.019

Table 3.

Analysis of significant TBBPA liver transcripts and pathways (1000 mg/kg)*.

Ingenuity Canonical Pathways −log(p-value) Ratio z-score Molecules
Interferon Signaling 8.85E00 1.94E-01 2.449 OAS1,IRF9,STAT1,IFIT3,STAT2,ISG15,MX1
Activation of IRF by Cytosolic Pattern Recognition Receptors 4.47E00 7.94E-02 1.342 IRF9,IRF7,STAT1,STAT2,ISG15
Cell Cycle: G1/S Checkpoint Regulation 3.27E00 6.25E-02 −1.000 E2F6,GSK3B,CDKN1A,HDAC4
Cyclins and Cell Cycle Regulation 2.94E00 5.13E-02 NaN E2F6,GSK3B,CDKN1A,HDAC4
Pancreatic Adenocarcinoma Signaling 2.46E00 3.77E-02 NaN E2F6,RALBP1,STAT1,CDKN1A
Acetyl-CoA Biosynthesis III (from Citrate) 2.23E00 1E00 NaN ACLY
Role of JAK1, JAK2 and TYK2 in Interferon Signaling 2.06E00 8.33E-02 NaN STAT1,STAT2
Estrogen-mediated S-phase Entry 2.06E00 8.33E-02 NaN E2F6,CDKN1A
JAK/Stat Signaling 2.06E00 4.17E-02 NaN STAT1,STAT2,CDKN1A
*

Analysis using ingenuity.com.