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A simplified diagnostic algorithm for the integrated diagnosis of lower-grade gliomas according to the 2016 WHO classification. Besides the IDH mutation and the chromosome 1p/19q codeletion, diffuse gliomas located along the midline should be tested also for the H3 K27M mutation. The presence of this molecular marker identifies in fact a distinct nosological entity (‘diffuse midline glioma, H3 K27M-mutant’) assigned WHO grade IV.
