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. 2017 Dec 11;14(1):81–84. doi: 10.1080/21645515.2017.1386360

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© 2018 Pfizer, Inc. Published with license by Taylor & Francis

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 1. — O-acetylation is necessary for an effective protective vaccine response in a murine pyelonephritis model. Female CD-1 mice (20/group) were immunized three times with 0.01 mcg of O-acetylated (native) CP5-CRM₁₉₇ with AlPO₄, de-O-acetylated CP5-CRM₁₉₇ with AlPO₄, or AlPO₄ alone, then challenged with S. aureus. Bacterial burden in the kidneys was determined two days after challenge.