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. 2017 Dec 11;14(1):81–84. doi: 10.1080/21645515.2017.1386360

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© 2018 Pfizer, Inc. Published with license by Taylor & Francis

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 2. — O-acetylation is necessary for capsular polysaccharide conjugates to induce effective opsonophagocytic killing responses. Female CD-1 mice (20/group) were immunized three times with 0.01 mcg of O-acetylated (native) CP5-CRM₁₉₇ with AlPO₄, de-O-acetylated CP5-CRM₁₉₇ with AlPO₄, O-acetylated (native) CP8-CRM₁₉₇ with AlPO₄, or de-O-acetylated CP8-CRM₁₉₇ with AlPO₄ and OPA titers from week 7 sera were assessed.