Figure 3.

Rewiring after Pathway Activation Partially Caused by Change in Gene Function

(A) Distribution of self-correlation of all tested genes between baseline and Wnt-active (left) or Apc-loss (right) state.

(B) Self-correlation (x axis) and maximal association (y axis) after pathway induction. The maximal association represents the highest absolute PCC of each gene in the Wnt-active state. The color illustrates positive (red) or negative (green) single knockdown Wnt signaling phenotypes in the Wnt-active state.

(C) Zoomed-in networks illustrate state-specific similarity (PCC > 0.65) between selected genes with a low autocorrelation.

(D) Change of genetic interaction profiles of JNK signaling transcription factors Jra and kay from baseline to Wnt-active state.

(E) Self-correlation of Jra and kay between baseline and Wnt-active state.