Fig 4.

Prognostic effects of baseline chromogranin A (CgA), neuron-specific enolase (NSE), and angiogenic biomarkers. bFGF, basic fibroblast growth factor; PIGF, placental growth factor; SVEGFR, soluble VEGF receptor; VEGF, vascular endothelial growth factor. (*) Elevated baseline CgA was defined as > 2× upper limit of normal. (†) Elevated baseline NSE was defined as > 1× upper limit of normal. (‡) P values are nominal without adjustment for multiple testing. For all angiogenic biomarkers, the median of distribution was used to define the threshold for elevated biomarker levels.