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. Author manuscript; available in PMC: 2018 Jan 31.
Published in final edited form as: Nat Genet. 2016 Nov 21;49(1):65–74. doi: 10.1038/ng.3722

Figure 2. Analysis of the TERT locus: a CESAM pan-cancer hit.

Figure 2

(a) Depiction of the TERT locus, the abnormal expression of which CESAM inferred to be mediated by cis SCNAs, for adrenocortical carcinoma (ACC) and summarized across cancer types (pan-cancer copy-number gains and losses). Gene expression values reflecting fold changes versus non-carrier ACC samples are indicated adjacent to each SCNA. (b) Fraction of donors per tumor type for which CESAM inferred TERT dysregulation along with SCNAs in cis in at least 3 donors (c) TERT expression values (unadjusted RSEM gene expression values) for different cancer types broken down by SCNA class (see Supplementary Table 1 for tumor-type abbreviations).