Table 3. Incremental predictive value of textural parameters for EGFR TKI failure.
| Base model | Base model adjusted with textural parametersa) | Base model adjusted with textural parameters and metabolic volume b) | |||
|---|---|---|---|---|---|
| Harrell's C-index (95%CI) |
P (vs. Base model) | P (vs. Base model) | |||
| Co-occurrence homogeneity | - | 0.650 (0.578–0.723) |
0.02 | 0.664 (0.582–0.745) |
0.03 |
|
Voxel-alignment intensity variability |
- | 0.644 (0.573–0.715) |
0.03 | 0.663 (0.582–0.743) |
0.03 |
| Neighborhood-intensity difference busyness | - | 0.631 (0.562–0.701) |
0.05 | 0.660 (0.580–0.739) |
0.03 |
|
Intensity size zone intensity variability |
- | 0.630 (0.558–0.702) |
0.06 | 0.661 (0.579–0.744) |
0.03 |
| Co-occurrence entropy | - | 0.631 (0.559–0.704) |
0.05 | 0.662 (0.580–0.745) |
0.02 |
|
Voxel-alignment short run emphasis |
- | 0.669 (0.597–0.741) |
0.01 | 0.671 (0.592–0.751) |
0.02 |
| Neighborhood-intensity difference contrast | - | 0.632 (0.560–0.704) |
0.11 | 0.671 (0.592–0.749) |
0.04 |
|
Intensity size zone high intensity zone emphasis |
- | 0.640 (0.565–0.715) |
0.08 | 0.679 (0.599–0.759) |
0.01 |
| SUV(max) | - | 0.633 (0.562–0.705) |
0.14 | 0.672 (0.593–0.751) |
0.02 |
| SUV(average) | - | 0.607 (0.528–0.687) |
0.61 | 0.664 (0.579–0.749) |
0.07 |
|
Initial disease status and ECOG PS |
0.596 (0.527–0.665) |
- | - | - | - |
a) Harrell’s C-index calculated by Cox-proportional regression models adjusted for initial disease status, and ECOG PS
b) Harrell’s C-index calculated by Cox-proportional regression models adjusted for initial disease status, ECOG PS, and SUV metabolic volume
Abbreviations: SUV = standardized uptake value, ECOG PS = Eastern Cooperative Oncology Group Performance Status