Table 1. The effect of increasing concentrations of pantoprazole on IC50^NIL in BCR-ABL1+ cell lines.

Cell Line	Transporter Expression		IC50NIL (nM)	Decrease (%)	p-value
	ABCB1	ABCG2
K562
Control (n = 6)	✘	✘	388
+50 μM PP (n = 3)	✘	✘	254	34	p = 0.012
+200 μM PP (n = 5)	✘	✘	217	44	p = 0.002
+500 μM PP (n = 4)	✘	✘	114	71	p = 0.0002
K562-Dox
Control (n = 5)	✔	✘	463
+50 μM PP (n = 3)	✔	✘	202	56	p = 0.021
+200 μM PP (n = 4)	✔	✘	201	57	p = 0.010
+500 μM PP (n = 3)	✔	✘	145	69	p = 0.010
K562-ABCG2
Control (n = 6)	✘	✔	261
+50 μM PP (n = 5)	✘	✔	122	53	p = 0.007
+100 μM PP (n = 5)	✘	✔	157	40	p = 0.041
+200 μM PP (n = 5)	✘	✔	120	54	p = 0.011
KU812
Control (n = 5)	✘	✘	305
+50 μM PP (n = 5)	✘	✘	149	51	p = 0.010
+100 μM PP (n = 5)	✘	✘	146	52	p = 0.011
+250 μM PP (n = 5)	✘	✘	117	62	p = 0.004

Statistical analyses were performed using Student’s t-test; NIL = nilotinib, PP = pantoprazole.