Skip to main content
. 2018 Jan 19;14(1):e1006822. doi: 10.1371/journal.ppat.1006822

Fig 2. IFNγ is required for survival but not control of HSV replication.

Fig 2

(A) HSV-infected WT, IL-10KO, GKO and Rag-/- mice were monitored for survival from HSE; data are representative of 3–5 experiments (n = WT: 40, IL-10KO: 22, GKO: 36, Rag-/-: 28 mice). ****p<0.0001; *p<0.05. (B) BS was isolated at the indicated time points from HSV-infected WT, IL-10KO, GKO or Rag-/- mice and virus titers determined by plaque assay (n = 8–10 mice per time point), *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001. p<0.0001 for all time points for Rag-/- mice compared to WT and IL-10KO mice. All Rag-/- mice had died by day 16 pi.