| Age, comorbidities, immune status, nutritional status, abusive alcohol intake, adherence to treatment, and drug tolerance |
| Genetic characteristics affecting drug absorption and metabolism, and individual vulnerability to toxicities |
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FACTORS RELATED TO THE ORGANISM/DISEASE PRESENTATION
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| Virulence of the organism |
| Susceptibility of the strain |
| Radiological extent of the disease and presence of cavities |
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CARE-RELATED FACTORS
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| Motivational capacity of the staff, access of patients to the health care system, and monitoring and supervision of patients regarding treatment |
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TREATMENT-RELATED FACTORS
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| Amount of each drug administered, plasma concentrations of administered drugs; relationship between administered drugs and proteins, clearance, metabolism, and absorption |
| Drug bioavailability of the presentations (single-drug tablets, fixed-dose combination tablets), and drug interactions with other drugs |
| Treatment regimen used (daily or intermittent), which influences duration and frequency of drug administration; bactericidal and sterilizing potency; and drug synergy or antagonism |
