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. 2017 Nov-Dec;43(6):472–486. doi: 10.1590/S1806-37562016000000388

Chart 3. Treatment of multidrug-resistant and extensively drug-resistant tuberculosis.

Resistance Phase Druga,b Body weight, kg Dose Treatment duration, months
R + H (± S) Intensive Cm3 30 15-20 mg/kg/day 8
31-45 500 mg/day
46-55 750 mg/day
56-70 1,000 mg/day
> 70 1,000 mg/day
E 30 15-25 mg/kg/day
31-45 800 mg/day
46-55 1,200 mg/day
56-70 1,200 mg/day
> 70 1,200 mg/day
Z 30 20-30 mg/kg/day
31-45 1,000 mg/day
46-55 1,500 mg/day
56-70 1,500 mg/day
> 70 2,000 mg/day
Lfx 30 10-15 mg/kg/day
31-45 500 mg/day
46-55 750 mg/day
56-70 1,000 mg/day
> 70 1,000 mg/day
Trd 30 10-20 mg/kg/day
31-45 500 mg/day
46-55 500 mg/day
56-70 750 mg/day
> 70 750 mg/day
Maintenance E 30 15-25 mg/kg/day 10
31-45 800 mg/day
46-55 1,200 mg/day
56-70 1,200 mg/day
> 70 1,200 mg/day
Lfx 30 10-15 mg/kg/day
31-45 500 mg/day
46-55 750 mg/day
56-70 1,000 mg/day
> 70 1,000 mg/day
Trd 30 10-20 mg/kg/day
31-45 500 mg/day
46-55 500 mg/day
56-70 750 mg/day
> 70 750 mg/day
R + H + E (± S) or R + H + E + Z (± S) Intensive Cm3 30 15-20 mg/kg/day 8
31-45 500 mg/day
46-55 750 mg/day
56-70 1,000 mg/day
> 70 1,000 mg/day
Et 30 15-20 mg/kg/day
31-45 500 mg/day
46-55 750 mg/day
56-70 750 mg/day
> 70 750 mg/day
Z 30 20-30 mg/kg/day
31-45 1,000 mg/day
46-55 1,500 mg/day
56-70 1,500 mg/day
> 70 2,000 mg/day
Lfx 30 10-15 mg/kg/day
31-45 500 mg/day
46-55 750 mg/day
56-70 1,000 mg/day
> 70 1,000 mg/day
Trd 30 10-20 mg/kg/day
31-45 500 mg/day
46-55 500 mg/day
56-70 750 mg/day
> 70 750 mg/day
Maintenance Et 30 15-20 mg/kg/day 10
31-45 500 mg/day
46-55 750 mg/day
56-70 750 mg/day
> 70 750 mg/day
Lfx 30 10-15 mg/kg/day
31-45 500 mg/day
46-55 750 mg/day
56-70 1,000 mg/day
> 70 1,000 mg/day
Trd 30 10-20 mg/kg/day
31-45 500 mg/day
46-55 500 mg/day
56-70 750 mg/day
> 70 750 mg/day
R + H + Z (± S) Intensive Cm3 30 15-20 mg/kg/day 8
31-45 500 mg/day
46-55 750 mg/day
56-70 1,000 mg/day
> 70 1,000 mg/day
E 30 15-25 mg/kg/day
31-45 800 mg/day
46-55 1,200 mg/day
56-70 1,200 mg/day
> 70 1,200 mg/day
Z 30 20-30 mg/kg/day
31-45 1,000 mg/day
46-55 1,500 mg/day
56-70 1,500 mg/day
> 70 2,000 mg/day
Lfx 30 10-15 mg/kg/day
31-45 500 mg/day
46-55 750 mg/day
56-70 1,000 mg/day
> 70 1,000 mg/day
Et 30 15-20 mg/kg/day
31-45 500 mg/day
46-55 750 mg/day
56-70 750 mg/day
> 70 750 mg/day
Trd 30 10-20 mg/kg/day
31-45 500 mg/day
46-55 500 mg/day
56-70 750 mg/day
> 70 750 mg/day
Maintenance E 30 15-25 mg/kg/day 10
31-45 800 mg/day
46-55 1,200 mg/day
56-70 1,200 mg/day
> 70 1,200 mg/day
Lfx 30 10-15 mg/kg/day
31-45 500 mg/day
46-55 750 mg/day
56-70 1,000 mg/day
> 70 1,000 mg/day
Et 30 15-20 mg/kg/day
31-45 500 mg/day
46-55 750 mg/day
56-70 750 mg/day
> 70 750 mg/day
Trd 30 10-20 mg/kg/day
31-45 500 mg/day
46-55 500 mg/day
56-70 750 mg/day
> 70 750 mg/day

R: rifampin; H: isoniazid; S: streptomycin; Cm: capreomycin; E: ethambutol; Z: pyrazinamide; Lfx: levofloxacin; Trd: terizidone; and Et: ethionamide. aThe subscript number after a drug abbreviation indicates the number of days per week that the drug will be used; if there is no subscript number, treatment with that drug is daily. bIn patients who have already used capreomycin, use amikacin as an alternative. In patients who do not have resistance to streptomycin as determined by drug susceptibility testing and who have not used amikacin, amikacin can also be considered for use. Doses of amikacin and streptomycin: up to 30 kg, 15-20 mg/kg/day; from 31 to 45 kg, 500 mg/day; from 46 to 55 kg, 750 mg/day; ≥ 56 kg, 1,000 mg/day.