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Mechanism and function for IEC stabilization of HIF by neutrophils: Neutrophils (PMN) consume oxygen in a respiratory burst via the NADPH oxidase complex (NOX2), with generation of antimicrobial superoxide anion (O2·−). The local depletion of oxygen results in HIF stabilization, nuclear translocation, and transactivation of HIF target genes, including barrier components such as mucins.
