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Arginase inhibition or endothelial cell (EC)-arginase 1 (A1) deletion prevents high-fat/high-sucrose (HFHS)-induced increase in arginase activity and A1 mRNA expression in isolated aortic endothelial cells. Effects of 2-(S)-amino-6-boronohexanoic acid (ABH) and EC-A1 deletion on mRNA levels of A1 (A) and arginase activity (B). Values are means ± SE; n = 6 mice. *P < 0.05 vs. wild-type (WT) normal diet (ND) or A1con ND groups.
